| ncRNA name | rno-miR-25 |
| ncRNA Category | miRNA |
| Disease name | age-related macular degeneration (AMD) |
| Species | Rattus norvegicus |
| Tissues/Cell_line | retinas |
| Methods | TUNEL assay, qPCR, Western blot, ELISA, chromatin immunoprecipitation (ChIP) |
| Expression pattern | up-regulated |
| Functional description | Our findings demonstrate that, in SI-treated rats, oxidative stress activates STAT3 signaling which up-regulates miR-25 expression, in a very early stage. The increased miR-25 then inhibits ITGAV and PEDF expressions, resulting in RPE phagocytosis dysfunction and then RPE apoptosis and visual impairment as observed in patients with AMD. |
| PubMed ID | 29210651 |
| Year | 2017 |
| Title | miR-25 Mediates Retinal Degeneration Via Inhibiting ITGAV and PEDF in Rat. |
| Drug-related ncRNA | NO |
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